History
  Links
  Research Groups. Scientific interests and academic production since 2003
  Neuroendocrinology and Immunology
  Systems biology/Eukaryotic cell biology
  Signal Transduction
  Plant Molecular Biology
  Eukaryotic molecular biology
  Neurosciences. Chromaffin cells
  Evolutionary genetics
  Molecular and cell biology
  Neurosciences. Neuronal networks
  Neuroscience. Neurological disorders
   

 

 

 

 

 

     
  Neuroscience
 
     
 

 
   
 


Group Leader
Osvaldo Daniel Uchitel (Investigador Superior CONICET, Profesor titular UBA)

Research Associates
Carlota Gonzáles Inchauspe (Investigadora Asistente CONICET), Francisco Urbano (categoría adjunto CONICET)

Graduate Students
Barbara Giugovaz Tropper (CONICET), Lorena Itatí Ibañez (UBA), Mariano Di Guilmi (CONICET), Silvana Nudler (CONICET, hasta abril 2005), Ramiro Pisnoy (Ramón Carillo – Arturo Oñativia), Rafael Pagani (ANPCyT – Wellcome, hasta noviembre 2005), Paula Perissinotti (CONICET)

Undergraduate Students
Elisa Filevich (UBA), Francisco Martín (2004)

Technicians
María Eugenia Martin, Silvina Estévez (hasta 2004), Ezequiel Darío Nuguer (hasta octubre de 2006)

Theses supervised

MSc Theses
Francisco Martini. Biológo.
Tema: “Corrientes de calcio somáticas en la postsinapsis del Cáliz de Held”. FCEN, UBA, 2004. Calificación: sobresaliente.

Lorena Itatí Ibañez. Bióloga.
Tema: “Estudio de corrientes de Ca2+ y exocitosis en células cromafines de ratones wild type y KO para subunidad a1A del canal P/Q y utilización de vectores virales como herramientas para la introducción de genes”. Facultad de Ciencias Biológicas, Universidad de San Luis, 2003.
Calificación: sobresaliente. Co-dirigida con el Dr. Fernando Marengo.

PhD Theses
Mario Rafael Pagani. Doctorado UBA en Cs. Biológicas.
Tema: “Potenciación Sináptica mediada por anticuerpos de pacientes con Esclerosis Lateral Amiotrófica”. FCEN, 2005.
Calificación: sobresaliente.

Silvana Nudler. Doctorado UBA en Cs. Biológicas.
Tema: “Modulación por testosterona de la expresión funcional de canales de calcio en la sinapsis neuromuscular”. FCEN, 2006.
Calificación: sobresaliente.

 
   
 


Research

Calcium channels and synaptic transmission in neurological syndromes

The long-term goal of this proposal is to understand how calcium influx regulates neuromuscular transmission in normal and disease conditions. Our specific aims are focused on learning how synaptic vesicles recycle to maintain neuromuscular transmission at low and high frequency activity in physiological conditions. We have identified at least two pools of synaptic vesicles. One of them is modulated by drugs that specifically affect L- type Ca2+ channel activity. We are planning to search for physiological pathways that may modulate neuromuscular transmission through the regulation of L-type Ca channel activity.

  Neuromuscular junction stained with FM2-10 dye by nerve stimulation with dye in the bath.
Figure shows destaining during nerve stimulation in the absence of dye in the bath.


 

Publications


Santafé et al. E. J. Neuroscience 17:119-127 (2003).
Urbano et al. Proc. Natl. Acad. Sci. USA. 100(6):3491-6 (2003)
Piriz et al. J. Pharm. and Exp. Therap. 306(2):658-63 (2003)
Nudler et al. In Myasthenia Gravis and Related Disorders: Xth International Conference. Edited by Mark A. Agius. Ann. of the NY Acad. of Sci. 998:11-17 (2003).
Pagani et al. Neuroscience 123(1):75-85 (2004).
Santafé et al. Neuroscience 123(1):61-73 (2004).
González Inchauspe et al. J. Neuroscience 17; 24(46):10379-83 (2004)
Nudler et al. Neuroscience 134(3):817-26 (2005)
Urbano et al. In Pumps, Transporters, and ion channels. Studies on Their Structure, Function, and Cell Biology, edited by Sepúlveda F.V. & Bezanilla F. Kluwer Academic/Plenum Publishers USA. Chapter 8. (2005).
Pagani et al. J. of Neuroscience. 26(10):2661-2672. (2006)

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