» Dr. Francisco J. Urbano

Líneas de investigación
Efecto de los psicoestimulantes sobre los sistemas tálamocorticales somatosensorial y motor de ratón.

  • Estudio de las alteraciones tálamocorticales mediadas por psicoestimulantes (Cocaína, metilfenidato, metanfetamina) en modelos de ratón.
  • Alteraciones del sueño mediadas por leptina y grelina en modelos murinos transgénicos. Rol de los núcleos Pedunculopontino y reticular talámico.

Publicaciones (2011-2015):

H-index (Scopus) = 17 (Google h=18)


 Goitia B, Rivero-Echeto MC, Weisstaub NV, Gingrich JA, Garcia-Rill E, Bisagno V, Urbano FJ. (2015-In Press). Modulation of gaba release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of Neurochemistry 2015 Oct 20. doi: 10.1111/jnc.13398. Factor de Impacto (FI 2014 ): 4.281.

González B, Rivero-Echeto C, Muñiz JA, Cadet JL, García-Rill E, Urbano FJ, Bisagno V (2015-In Press) Methamphetamine blunts Ca2+ currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex. Addiction Biology 2015 Apr 14. doi: 10.1111/adb.12249. Factor de Impacto (FI 2014 ): 5.359.
González CR, González B, Matzkin ME, Muñiz JA, Cadet JL, Garcia-Rill E, Urbano FJ, Vitullo AD & Bisagno V. (2015). Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System. PLoS One. 10(11):e0142713. doi: 10.1371/journal.pone.0142713. FI2014: 3.234.
 Brennon, L, D’Onofrio, SM, Urbano, FJ# & Garcia-Rill E# (2015). Threshold Ca2+ channels behind gamma band activity High in the pedunculopontine nucleus (PPN). Physiological Reports. 3(6). pii: e12431. doi: 10.14814/phy2.12431.  #Authors contributed equally as last authors.
 Inchauspe, CG, Pilati, N, Di Guilmi, MN, Urbano, FJ, Ferrari, MD, van den Maagdenberg, AM, Forsythe, ID & Uchitel, OD. (2015). Familial hemiplegic migraine type-1 mutated CaV2.1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. Hearing Research 319:56-68. doi: 10.1016/j.heares.2014.11.006. Factor de Impacto (FI2014): 2.848.
 D’Onofrio, SM, Kezunovic, N, Hyde, JR, Luster, B, Messias, E, Urbano, FJ# & Garcia-Rill, E.# (2015). Modulation of gamma in the pedunculopontine nucleus (PPN) by neuronal calcium sensor protein-1 (NCS-1): Relevance to schizophrenia and bipolar disorder. Journal of Neurophysiology 113(3):709-719. doi: 10.1152/jn.00828.2014. #Authors contributed equally as last authors. Factor de Impacto (FI2014): 3.226.
 Raineri, M, González, B, Rivero Echeto, C, Muñiz, JA, Gutierrez, ML, Ghanem, CI, Cadet, JL, García-Rill, E, Urbano, FJ & Bisagno V. (2015). Differential effects of environment-induced changes in body temperature on modafinil’s actions against methamphetamine-induced striatal toxicity in mice. Neurotoxicity Research 27(1):71-83. doi: 10.1007/s12640-014-9493-9. PMCID 25261212. FI2013: 3.339.
 Gonzalez B, Raineri M, Cadet JL, García-Rill E, Urbano FJ & Bisagno V. (2014) Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice. Neuropharmacology. 87:188-197. doi: 10.1016/j.neuropharm.2014.02.002. (Online 2014 Feb 12). PMCID24530829.doi: 10.1016/j.neuropharm.2014.02.002. FI2013: 4.701.
 Urbano FJ*,#, Lino NG#, González-Inchauspe CM, González LE, Colettis N, Vattino LG, Wunsch AM, Wemmie JA & Uchitel OD. (2014) Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice. American Journal of Physiology. Cell Physiology306(4):C396-C406. (Online 2013 Dec 11). PMCID24336653. # Authors contributed equally. * Corresponding author. doi: 10.1152/ajpcell.00301.2013. FI2013: 3.856
Kezunovic N, Hyde J, Goitia B, Bisagno V, Urbano FJ# & Garcia-Rill E#. (2013). Muscarinic modulation of high frequency oscillations in pedunculopontine neurons. Frontiers in Neurology; Cronobiology & Sleep 4:176. # Authors contributed equally as last authors. PMCID24223570. doi: 10.3389/fneur.2013.00176. eCollection 2013.FI2013: 2.492.
Hyde JR, Kezunovic N, Urbano FJ# & Garcia-Rill E#. (2013) Spatiotemporal properties of high speed calcium oscillations in the pedunculopontine nucleus. Journal of Applied Physiology (1985). 115(9):1402-1414. (Online Aug 29, 2013). # Authors contributed equally as last authors. PMCID23990242. doi: 10.1152/japplphysiol.00762.2013. FI2013: 3.562.
Beck P, Mahaffey S, Urbano FJ# & Garcia-Rill E#. (2013) Role of G-proteins in the effects of leptin on pedunculopontine nucleus (PPN) neurons. Journal of Neurochemistry. 126(6): 705-714. (Online May 20 2013) # Authors contributed equally as last authors. PMCID23692342. doi: 10.1111/jnc.12312. FI2013: 4.359.
Hyde J, Kezunovic N, Urbano FJ# & Garcia-Rill E#.(2013) Visualization of fast calcium oscillations in the parafascicular nucleus. Pflügers Archiv-European Journal of Physiology465(9): 1327-1340. (On line Apr 16 2013) # Authors contributed equally as last authors. PMCID23588378. doi: 10.1007/s00424-013-1264-6. FI2013: 3.253.
Beck P, Urbano FJ, Williams DK & Garcia-Rill E. (2013). Effects of leptin on pedunculopontine nucleus (PPN) neurons. Journal of Neural Transmission120(7):1027-1038. PMCID23263542. doi: 10.1007/s00702-012-0957-x. FI2013: 2.962.
Goitia B, Raineri M, González LE, Rozas JL, Garcia-Rill E, Bisagno V & Urbano FJ. (2013). Differential effects of methylphenidate and cocaine on GABA transmission in sensory thalamic nuclei. Journal of Neurochemistry.124(5): 602-612. PMCID23205768. doi: 10.1111/jnc.12113.FI2013: 4.359.
Weissmann C, Di Guilmi MN, Urbano FJ & Uchitel OD (2013). Acute effects of pregabalin on the function and cellular distribution of CaV2.1 in HEK293t cells. Brain Research Bulletin.90:107-113. PMCID 23063705. doi: 10.1016/j.brainresbull.2012.10.001.FI2013: 3.052.
González Inchauspe C, Urbano FJ, Di Guilmi MN, Ferrari MD, van den Maagdenberg AM, Forsythe I & Uchitel OD. (2012). Presynaptic Cav2.1 calcium channels carrying a familial hemiplegic migraine mutation R192Q allow faster recovery from synaptic depression in mouse calyx of held. Journal of Neurophysiology108(11):2967-2976. PMCID22956801. doi: 10.1152/jn.01183.2011. FI2012: 3.573.
Raineri M#, Gonzalez B#, Goitia B, Garcia-Rill E, Krasnova IN, Cadet JL, Urbano FJ & Bisagno V. (2012). Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum.Plos ONE 7(10):e46599. #contributed equally. PMID:23056363. doi: 10.1371/journal.pone.0046599. FI2012: 3.965.
Kezunovic N, Hyde JR, Simon C, Urbano FJ, Williams DK & Garcia-Rill E (2012). Gamma band activity in the developing parafascicular nucleus (Pf). Journal of Neurophysiology. 107(3):772-784. PMCID 22090455. doi: 10.1152/jn.00677.2011. FI2012: 3.573.
Giugovaz-Tropper B, González-Inchauspe C, Di Guilmi MN, Urbano FJ, Forsythe ID & Uchitel OD (2011). P/Q-type calcium channel ablation in a mice glycinergic synapse mediated by multiple types of Ca²+ channels alters transmitter release and short term plasticity. Neuroscience192: 219-230. PMCID21718757. doi: 10.1016/j.neuroscience.2011.06.021.FI2011: 3.72.
Kezunovic N, Urbano FJ, Simon C, Hyde J, Smith K & Garcia-Rill E (2011). Mechanism behind gamma band activity in the pedunculopontine nucleus (PPN). European Journal of Neuroscience34(3):404-415. PMCID21722210.FI2011: 4.047.
Simon C, Kezunovic N, Williams DK, Urbano FJ & Garcia-Rill E (2011). “Cholinergic and glutamatergic agonists induce gamma frequency activity in dorsal subcoeruleus nucleus neurons”. American Journal of Physiology – Cell Physiology 301(2):C327-C335. PMCID 21543743.FI2011: 4.034.
Raineri M, Peskin V, Goitia B, Taravini IRE, Giorgeri S, Urbano FJ & Bisagno V (2011). Attenuated methamphetamine induced neurotoxicity by modafinil administration in mice. Synapse65(10):1087-98. PMCID21590747.FI2011: 3.148.
Di Guilmi MN, Urbano FJ, Gonzalez-Inchauspe C & Uchitel OD (2011). Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of CaV2.1 calcium channels.. Journal of Pharmacology and Experimental Therapeutics. 336(3):973-982. PMCID21177783. Subject to an editorial special mention.FI2011: 4.167.

Reviews (2011-2015):

Garcia-Rill E, Luster B, D'Onofrio S, Mahaffey S, Bisagno V & Urbano FJ. (2015-In Press). Implications of gamma band activity in the pedunculopontine nucleus. Journal of Neural Transmission (Vienna) 2015 Nov 23. Factor de Impacto (FI 2014 ): 2.402. doi: 10.1007/s00702-015- 1485-2.
Garcia-Rill E, Luster B, D’Onofrio S, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology – Deep brain stimulation (DBS). Sleep Science 8(3):153-161. doi: j.slsci.2015.09.001 1984- 0063.
 Urbano FJ, Bisagno V, González B, Rivero-Echeto MC, Muñiz JA, Luster B, D’Onofrio S, Mahaffey S & Garcia-Rill E (2015). Pedunculopontine arousal system physiology—Effects of psychostimulant abuse. Sleep Science 8(3):162-168. doi: 10.1016/j.slsci.2015.09.004.
Garcia-Rill E, D'Onofrio SM, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology- implications for insomnia. Sleep Science 8(2):92-99. doi:10.1016/j.slsci.2015.06.002.
Garcia-Rill E, D'Onofrio SM, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology- implications for schizophrenia. Sleep Science 8(2):82-91. doi:10.1016/j.slsci.2015.04.003.
 Garcia-Rill E, Luster B, D’Onofrio S, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology – Deep brain stimulation (DBS). Sleep Science 8(3):153-161. doi: j.slsci.2015.09.001 1984-0063.
 Urbano FJ, Bisagno V, González B, Rivero-Echeto MC, Muñiz JA, Luster B, D’Onofrio S, Mahaffey S & Garcia-Rill E (2015). Pedunculopontine arousal system physiology—Effects of psychostimulant abuse. Sleep Science 8(3):162-168. doi: 10.1016/j.slsci.2015.09.004.
 Garcia-Rill E, D’Onofrio SM, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology- implications for insomnia. Sleep Science 8(2):92-99. doi:10.1016/j.slsci.2015.06.002.
 Garcia-Rill E, D’Onofrio SM, Mahaffey S, Bisagno V & Urbano FJ (2015). Pedunculopontine arousal system physiology- implications for schizophrenia. Sleep Science 8(2):82-91. doi:10.1016/j.slsci.2015.04.003.
 Garcia-Rill E, Hyde J, Kezunovic N, Urbano FJ & Petersen E. (2015) The physiology of the pedunculopontine nucleus: implications for deep brain stimulation. Journal of Neural Transmission (Vienna) 122(2): 225-235. doi: 10.1007/s00702-014-1243-x. FI2013: 2.962.
 Urbano, FJ, D’Onofrio, S, Luster, B, Beck, PB, Hyde, J, Bisagno, V & Garcia-Rill, E. (2014).Pedunculopontine Nucleus Gamma Band Activity- Preconscious Awareness, Waking, and REM Sleep. Frontiers in Neurology, Sleep and Chronobiology. 5:210. doi: 10.3389/fneur.2014.00210. eCollection 2013. FI2013: 2.492.
 Garcia-Rill E, Kezunovic N, D’Onofrio S, Luster B, Hyde J, Bisagno V & Urbano FJ. (2014) Gamma band activity in the RAS-intracellular mechanisms. Experimental Brain Research. 232(5):1509-1522.(Online 2013 Dec 6). PMCID24309750.doi: 10.1007/s00221-013-3794-8. FI2013: 2.306.
 Garcia-Rill E, Kezunovic N, Hyde JR, Simon C, Beck P & Urbano FJ (2013). Coherence and frequency in the reticular activating system (RAS). Sleep Medicine Reviews. 17(3): 227-238. PMCID23044219.doi: 10.1016/j.smrv.2012.06.002. FI2013: 9.141.
 Urbano FJ, Kezunovic N, Hyde JR, Simon C, Beck P & Garcia-Rill E (2012). Gamma band activity in the reticular activating system. Frontiers in Neurology, Sleep and Chronobiology3:6. doi: 10.3389/fneur.2012.00006. PMCID 22319508. FI2012: 1.633.
 A commentary on “Gamma band activity in the reticular activating system (RAS)” by Datta S. “The preconscious mind and gamma band activity in the reticular activating system”. (2012). Frontiers in Neurology, Sleep and Chronobiology3:6. doi: 10.3389/fneur.2012.00006.
 Uchitel OD, Inchauspe CG, Urbano FJ & Di Guilmi MN (2012). Ca(V)2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis. Journal of Physiology Paris. 106(1-2):12-22.doi: 10.1016/j.jphysparis.2011.10.004. FI2012: 1.134.

Capítulos de libros

Urbano FJ, Bisagno V. & Garcia-Rill E. (2015). Drug Abuse & Reticular Activating System. In: Waking and
Reticular Activating System in Helath and Disease. Editor: Garcia-Rill. Pag.: 277-289. ISBN 978-0- 12-801385- 4.
Academic Press, Elsevier. The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK.

Bisagno V, Fantegrossi WE & Urbano FJ (2012). “Translational Studies in Drug Abuse”, in: Translational
Neuroscience, ISBN: 978-0- 470-96071- 4. Pag. 67-79. Editor: Garcia-Rill E. John Wiley & Sons, Inc. Chichester,
West Sussex, PO19 85Q, UK. 

Proyectos financiados en vigencia

Como investigador responsable:

  • Rol de la leptina y la grelina en la regulación de los ciclos sueño-vigilia. Caracterización de la modulación por leptina y grelina de las propiedades intrínsecas de las neuronas del tronco del encéfalo y reticular del tálamo de ratón”. INVESTIGADOR PRINCIPAL: Dr. Francisco J. Urbano (IFIBYNE, CONICET). ENTIDAD FINANCIADORA: ANPCyT-FONCYT (PICT 2012-1769) Total subsidio: ARG $ 329.995. DURACIÓN: Ene. 2014-Ene. 2018.

Como integrante/colaborador:

  • “Efectos nocivos del consumo combinado de los estimulantes cocaína y cafeína en un modelo animal: alteraciones del sistema tálamocortical y su impacto sobre las transiciones sueño-vigilia”;iNVESTIGADOR PRINCIPAL: Dr. Verónica Bisagno (ININFA-CONICET). Co-Investigador responsable Dr. Francisco J. Urbano (IFIBYNE, CONICET). ENTIDAD FINANCIADORA: ANPCyT-FONCYT (PICT-2012- 0924). Total subsidio: ARG $ 329.992. DURACIÓN: Ene. 2014-Ene. 2017.
  • “Análisis de los cambios de pH durante las transmisión sináptica y sus efectos sobre la liberación de neurotransmisor mediados por los ASICs. Rol de los ASICs. En la fatiga del músculo esquelético”. INVESTIGADOR PRINCIPAL: Dr. Osvaldo D. Uchitel (IFIBYNE-CONICET). Co-Investigador responsable Dr. Francisco J. Urbano (IFIBYNE, CONICET). ENTIDAD FINANCIADORA: ANPCyT-FONCYT (PICT – 2011- 2667). Total subsidio: ARG $ 1.248.000,00. DURACIÓN: Agosto. 2013-Julio 2017.

Premios recibidos

  • 2011 Beca de la Fundación John Simon Guggenheim Memorial

Change Language

Integrantes del Grupo

INVESTIGADOR A CARGO

Dr. Francisco J. Urbano

Dr. Francisco J. Urbano
Investigador independiente
CONICET


Dr. Verónica Bisagno

Dra. Verónica Bisagno 
Research Scientist, CONICET, ININFA, Argentina.

BECARIOS

Lic. Celeste Rivero Echeto

Lic. Celeste Rivero Echeto
Biology (Director; Beca Doctoral CONICET)

COLABORACIONES CON OTROS GRUPOS

Dr. Edgar Garcia-Rill 
(Director, Center for Translational Neuroscience, Department of Neurobiology & Developmental Sciences, College of Medicine University of Arkansas for Medical Sciences, Little Rock, Arkansas, U.S.A.).

INVESTIGADOR SUPERIOR

Dr. Osvaldo Uchitel

Dr. Osvaldo Daniel Uchitel
Investigador Superior CONICET
Profesor titular UBA
[+] Más Información